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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Cancer Lett. 2011 Mar 15;306(1):85–91. doi: 10.1016/j.canlet.2011.02.035

Fig. 1.

Fig. 1

Resistance to cetuximab-mediated inhibition of Akt and Erk phosphorylation in cells transfected with a constitutively active H-Ras. A431 cells transfected with a control vector (A431V) or an expression vector containing constitutively active H-RasG12V (A431-Ras) were left untreated or were treated with 20 nM cetuximab for 16 h in serum-free medium. Cell lysates were prepared and analyzed for the levels of total and phosphorylated Akt, total and phosphorylated Erk, and His-tagged Ras by Western blot analysis with respective antibodies.