Table 1.
Predicted 32 genes related to IFN-γ and vaccine networks.
| Gene | Degree | Eigenvector | Betweenness | Closeness | Reference (PMID) |
|---|---|---|---|---|---|
| IL2 | + | + | + | + | 8459207 |
| TNF | + | + | + | + | 16446013 |
| IL10 | + | + | + | + | 10930151 |
| IL6 | + | + | + | + | 10225849 |
| IL4 | + | + | + | + | 8519092 |
| CSF2 | + | + | + | + | 19459853 |
| IL8 | + | + | + | + | 11378044 |
| IL5 | + | + | - | + | 11138639 |
| NFKB1 * | + | + | + | + | 16971487 |
| IL13 | + | + | + | + | 12232042 |
| CD4 | + | + | + | + | 17298856 |
| TLR2 * | + | + | + | - | 12874299 |
| IL7 | + | - | + | + | 17496983 |
| IL18 | + | - | - | + | 19467215 |
| EIF2AK2 | + | + | + | - | 19596385 |
| CD40LG | + | + | + | + | 11403919 |
| CD40 | + | + | - | - | 11403919 |
| CD28 | + | + | - | - | 12594842 |
| C3 | + | + | + | - | 19477524 |
| TLR4 ** | + | - | - | - | 12874299 |
| TP53 ** | - | + | - | - | 10379742 |
| FCGR2B ** | - | + | - | - | 12874345 |
| CD46 | - | + | + | - | 11757799 |
| NCAM1 * | - | - | + | + | 16316416 |
| CXCL10 * | - | - | + | - | 10799249 |
| CD86 * | - | - | + | - | 12594842 |
| HSPD1 | - | - | + | - | 12218165 |
| IFNA1 | - | - | - | + | 19667099 |
| CCL2 * | - | - | - | + | 19833737 |
| TPBG | - | - | - | + | 16630022 |
| GNLY | - | - | - | + | 10644038 |
| CD8A | - | - | - | + | 18425263 |
These genes were ranked among the top 20 by at least one of the centrality measures in the literature-mined IFN-γ and vaccine network using VO (i.e. IFNG-vaccine-VO network). The sign “+” means that a gene is ranked among top 20 with the corresponding centrality measure. The sign “-” indicates the opposite. Genes marked with * were not ranked high in the IFNG-vaccine network built without using the VO (i.e. IFNG-vaccine network). Genes marked with ** were not found in the IFNG-vaccine network. The PubMed PMIDs are listed to affirm that the associations mined are verified by literature.