Table.
Mortality per 100 PY and univariate and multivariate Poisson regression models to assess risk factors associated with mortality among HIV infected individuals in Pune, India
| Characteristics | Deaths/n | PY† | Death / 100 PY* | Univariate models |
Multivariate model |
P value | |
|---|---|---|---|---|---|---|---|
| RR (95% CI) | P value | RR (95% CI) | |||||
| All | 83 / 457 | 632 | 13.13 (10.58, 16.27) | - | - | - | - |
| Gender | |||||||
| Female | 3 / 64 | 87 | 3.43 (1.10, 10.63) | Reference | Reference | ||
| Male | 80 / 393 | 545 | 14.68 (11.79, 18.27) | 4.28 (1.35, 13.56) | 0.013 | 1.83 (0.57, 5.92) | 0.311 |
| Age (yr) | |||||||
| < 35 | 29 / 257 | 362 | 8.01 (5.57, 11.54) | Reference | Reference | ||
| ≥ 35 | 54 / 200 | 271 | 19.93 (15.27, 26.03) | 2.48 (1.58, 3.90) | 0.001 | 1.97 (1.23, 3.14) | 0.005 |
| Opportunistic Infection | |||||||
| Absent | 22 / 243 | 328 | 6.70 (4.41, 10.18) | Reference | Reference | ||
| Presence of TB | 43 / 113 | 162 | 26.62 (19.74, 35.89) | 3.97 (2.37, 6.64) | < 0.001 | 2.38 (1.38, 4.09) | 0.002 |
| Presence of OI other than TB | 18 / 101 | 143 | 12.60 (7.94, 20.01) | 1.88 (1.01, 3.51) | 0.047 | 1.28 (0.68, 2.44) | 0.445 |
| Baseline CD4 count‡ (cells / µl) | |||||||
| 351+ | 2 / 128 | 189 | 1.06 ((0.26, 4.22) | Reference | Reference | ||
| 201-350 | 10 / 115 | 160 | 6.23 (3.35, 11.58) | 5.90 (1.29, 26.93) | 0.022 | 4.82 (1.03, 22.49) | 0.046 |
| 101-200 | 18 / 102 | 155 | 11.61 (7.31, 18.43) | 10.99 (2.55, 47.50) | 0.001 | 7.72 (1.69, 35.19) | 0.008 |
| ≤ 100 | 52 / 110 | 124 | 42.06 (32.05, 55.20) | 39.84 (9.70, 160.53) | < 0.001 | 33.20 (7.59, 145.29) | < 0.001 |
| Baseline viral load § (copies/ml) | |||||||
| <10000 | 5 / 94 | 133 | 3.76 (1.56, 9.03) | Reference | Reference | ||
| ≥10000 | 76 / 359 | 496 | 15.30 (12.23, 19.17) | 4.07 (1.64, 10.07) | 0.002 | 1.34 (0.52, 3.47) | 0.553 |
| ART status | |||||||
| ART received | 17 / 141 | 235 | 7.25 (4.50, 11.65) | Reference | Reference | ||
| ART naive | 66 / 398 | 398 | 16.59 (13.03, 21.11) | 2.29 (1.34, 3.90) | 0.002 | 5.60 (3.18, 9.86) | < 0.001 |
*
95 % CI denotes confidence interval and calculated using ‘Byar approximation to Poisson’; PY, person years; OI, opportunistic infections; ART, anti retroviral therapy; TB, tuberculosis (pulmonary and/or extra pulmonary);
†
Person years were computed to two decimal places and were rounded to whole numbers;
‡
Baseline CD4 count available in 455 patients,
§
baseline viral load available in 453 patients