Scheme 4. Synthesis of D-Ring Precursors for 9-Amino-8-azatetracyclines.
Reagents and conditions: (i) BocNH2, Pd2dba3, Xantphos, Cs2CO3, 1,4-dioxane, 80 °C; (ii) Boc2O, DMAP, DMF.
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