Table 1. In Vitro Antibacterial Activity of 7-Substituted-8-azatetracyclines.

		MIC (μg/mL)
		S. aureus			S. pneumoniae		E. coli		K. pneumoniae
compd	R1	wild typea	tet(M)b	tet(K)c	wild typed	tet(M)c	wild typee	tet(A)c	wild typef
20a	H	1	32	16	0.25	32	0.5	>32	1
20b	Cl	1	32	32	1	32	2	>32	4
20d	CH3	1	32	0.5	0.25	>32	1	>32	1
20e	Ph	0.063	32	1	0.031	4	0.5	>32	2
20f	(CH3)2N-	0.031	16	2	0.063	8	0.125	>32	0.25
20g	CH3O-	0.125	8	4	0.063	16	0.25	>32	1
20i	F	0.063	8	8	0.016	8	0.25	>32	0.5
tetracycline		1	>32	32	0.25	32	2	>32	4
minocycline		0.125	16	0.25	<0.016	8	0.5	8	1

^aATCC 13709.

^bObtained from Micromyx (Kalamazoo, MI).

^cObtained from Marilyn Roberts’ lab at the University of Washington.

^dATCC 49619.

^eATCC 25922.

^fATCC 13883.