Table 8. IV Efficacy in Mouse Septicemia Modela.
|
S. aureus |
E. coli |
|||||
|---|---|---|---|---|---|---|
| compd | MIC (μg/mL) | PD50 (mg/kg) | 95% C.I. | MIC (μg/mL) | PD50 (mg/kg) | 95% CI |
| 20f | 0.031 | <0.30b | 0.13 | 4.3 | 4.1−4.6 | |
| 24l | 0.5 | 0.36 | 0.36−0.56 | 0.5 | 17 | 4.1−30 |
| tetracycline | 0.25 | 0.35 | 0.34−0.37 | 1 | 17 | 7.3−27 |
| tigecycline | 0.063 | 0.35 | 0.24−0.47 | 0.13 | 2.1 | 1.8−2.4 |
a
S. aureus ATCC 13709 (Smith) or E. coli ATCC 25922 was mixed with 5% mucin and inoculated by intraperitoneal injection at 2.1 × 106 cfu/mouse (S. aureus) or 2.0 × 107 cfu/mouse (E. coli). One hour postchallenge, mice received IV treatment (vehicle = sterile water) with the test article at concentrations ranging from 0.05−10 mg/kg (S. aureus) or 0.30−30 mg/kg (E. coli). The PD50 in mg/kg was calculated as survival after 48 h.
b
Lowest dose was 0.30 mg/kg with 100% survival at all doses.