Table 3.

Risk of histology progression

	Risk of progression*		Comparison† (treated/observed)
	Observation	Treated	Odds ratio (95% CI)	P
All subjects
n	27	48
Maximum	15 (55.6%)	24 (50.0%)	0.97 (0.36–2.66)	0.95
Average	20 (74.1%)	27 (56.2%)	0.48 (0.17–1.37)	0.17
Dysplasia index	19 (70.4%)	23 (47.9%)	0.39 (0.14–1.10)	0.08
Current smokers
n	12	21
Maximum	4 (33.3%)	11 (52.4%)	2.67 (0.55–12.98)	0.22
Average	9 (75.0%)	12 (57.1%)	0.44 (0.09–2.16)	0.31
Dysplasia Index	9 (75.0%)	10 (47.6%)	0.28 (0.05–1.45)	0.13
Former smokers
n	15	27
Maximum	11 (73.3%.)	13 (48.1%)	0.41 (0.10–1.71)	0.22
Average	11 (73.3%,)	15 (55.6%)	0.52 (0.13–2.15)	0.37
Dysplasia index	10 (66.7%)	13 (48.1%,)	0.48 (0.13–1.83)	0.28

^*Progression defined as worsening of a subject’s histologic score or failure to obtain a follow-up bronchoscopy.

^†Adjusted for baseline histology (either maximum, average, or dysplasia index). All subject analysis is also adjusted for smoking status.