Table 4.

Change in histology measures

	Observation	Treated	Difference* (treated – observed)
			Difference	95% CI	P
All subjects
n	19	36
Maximum	0.37 (2.34)	0.03 (1.61)	−0.18	(−1.16 to 0.81)	0.72
Average	0.14 (0.88)	−0.17 (1.04)	−0.25	(−0.77 to 0.28)	0.35
Dysplasia index	0.00 (0.29)	−0.04 (0.26)	−0.02	(−0.16 to 0.12)	0.75
Current smokers
n	9	15
Maximum	−0.56 (1.24)	0.00 (1.81)	0.69	(−0.77 to 2.15)	0.34
Average	0.01 (0.93)	−0.32 (1.34)	−0.19	(−1.27 to 0.88)	0.71
Dysplasia index	0.00 (0.35)	−0.11 (0.32)	−0.04	(−0.33 to 0.24)	0.76
Former smokers
n	10	21
Maximum	1.20 (2.82)	0.05 (1.50)	−0.92	(−2.31 to 0.47)	0.18
Average	0.26 (0.87)	−0.07 (0.78)	−0.31	(−0.84 to 0.23)	0.25
Dysplasia index	0.01 (0.24)	0.01 (0.20)	0.00	(−0.15 to 0.14)	0.97

^*Adjusted for baseline histology (either maximum, average, or index). All subject analysis is also adjusted for smoking status.