Table 6.
Change in Ki67
| Observation | Treated | Difference* (treated – observed)
|
|||
|---|---|---|---|---|---|
| Difference | 95% CI | P | |||
| All subjects | |||||
| n | 17 | 32 | |||
| Maximum | −5.14 (34.55) | −8.09 (33.04) | −1.48 | (−18.24 to 15.29) | 0.86 |
| Average | 5.63 (21.22) | −1.68 (19.20) | −4.69 | (−15.94 to 6.57) | 0.41 |
| Ki67 fraction | 0.04 (0.40) | 0.03 (0.38) | −0.02 | (−0.23 to 0.20) | 0.88 |
| Current smokers | |||||
| n | 9 | 14 | |||
| Maximum | −10.00 (36.92) | −13.77 (38.83) | 3.58 | (−22.47 to 29.62) | 0.78 |
| Average | 5.31 (27.29) | −1.63 (22.54) | −3.54 | (−23.64 to 16.56) | 0.72 |
| Ki67 Fraction | −0.01 (0.49) | 0.07 (0.38) | 0.04 | (−0.32 to 0.40) | 0.81 |
| Former smokers | |||||
| n | 8 | 18 | |||
| Maximum | 0.34 (33.27) | −3.67 (28.12) | −3.93 | (−26.28 to 18.42) | 0.72 |
| Average | 5.99 (13.31) | −1.73 (16.84) | −5.76 | (−18.87 to 7.35) | |
| Ki67 fraction | 0.09 (0.30) | −0.01 (0.38) | −0.08 | (−0.36 to 0.20) | 0.57 |
*
Adjusted for baseline Ki67 level (either maximum, average, or fraction) “All subject” analysis is also adjusted for smoking status. Ki67 fraction is proportion of all samples within the individuals in which the Ki67 percentage exceeds 15%.