Table 7.

Toxicities

Toxicity	Observation (25 subjects): subjects with toxicity (grade toxicity)	13-Cis RA (22 subjects): subjects with toxicity (grade toxicity)	13-Cis RA/α toco (25 subjects): subjects with toxicity (grade toxicity)
Gastrointestinal	1 (1)	1 (1)	8 (1)
Musculoskeletal	4 (1)	6 (1). 2 (2)	3 (1). 3 (2)
Eye	1 (1)	7 (1), 4 (2)	7 (1), 2 (2)
Skin	6 (1). 2 (2)	7 (1). 5 (2)	18 (1), 6 (2)
Triglyceride	10 (1)	8 (1), 4 (2), 2 (3)	10 (1), 2 (2)
Cholesterol	4 (1)	1 (1)	9 (1), 1 (2)
Glucose	7 (1), 2 (2)	1 (1), 2 (2). 1 (3)	6 (1)
Liver function	9 (1), 2 (2)	10 (1), 2 (2)	17 (1), 1 (2)
Uric acid	6 (1), 1 (3)	5 (1), 4 (2), 1 (4)	4(1), 1 (2). 1 (4)