Table 1.
Total (bound and free) plasma concentrations (μg/mL; mean ± 1 SD) of cefovecin in nonhuman primates
| Time (h) after | Cynomolgus macaques | Olive baboons | Rhesus macaques |
||
| administration | IV | SC | IV | SC | SC |
| 0.25 | 72.4 ± 23.3 | 48.4 ± 7.73 | 125 ± 17.1 | 21.3 ± 4.46 | 46.1 ± 25.7 |
| 0.5 | 68.6 ± 9.45 | 61.0 ± 11.1 | 103 ± 13.4 | 46.5 ± 7.86 | 69.4 ± 15.0 |
| 1 | 60.4 ± 8.59 | 61.4 ± 14.8 | 87.5 ± 16.8 | 72.1 ± 6.10 | 93.7 ± 6.61 |
| 3 | 37.9 ± 5.54 | 49.6 ± 16.5 | 56.9 ± 13.1 | 74.4 ± 8.61 | 74.8 ± 8.13 |
| 6 | 22.7 ± 5.67 | 29.4 ± 11.2 | 37.7 ± 8.16 | 57.3 ± 10.2 | 47.5 ± 9.83 |
| 8 | 17.1 ± 3.69 | 23.8 ± 12.2 | 29.3 ± 6.02 | 45.9 ± 11.4 | 37.3 ± 10.6 |
| 24 | 1.97 ± 0.809 | 3.49 ± 4.61 | 7.65 ± 1.16 | 12.9 ± 5.68 | 7.33 ± 2.92 |
| 32 | 0.845 ± 0.544 | 1.77 ± 2.47 | 3.97 ± 0.902 | 7.37 ± 4.20 | 4.17 ± 2.29 |
| 48 | 0.0774 ± 0.0660 | 0.292 ± 0.608 | 1.62 ± 0.472 | 2.19 ± 1.39 | 1.81 ± 1.40 |
| 72 | 0.0111 ± 0.00890 | 0.0325 ± 0.0669 | 0.291 ± 0.132 | 0.442 ± 0.362 | 0.411 ± 0.388 |
| 96 | 0.00288 ± 0.00176 | 0.00905 ± 0.0182 | 0.0528 ± 0.0270 | 0.149 ± 0.177 | 0.121 ± 0.112 |
| 120 | not done | not done | 0.0160 ± 0.0101 | 0.0328 ± 0.0373 | 0.0323 ± 0.0309 |
| 168 | not done | not done | 0.00369 ± 0.00175 | 0.00551 ± 0.00462 | 0.00720 ± 0.00647 |
All dose groups contained 6 animals (3 male and 3 female), except for rhesus macaques (4 male and 2 female).
All animals received a single dose of cefovecin (8 mg/kg SC or IV).