Indication | First Choice | Alternatives |
---|---|---|
Prevention of late bacterial infections with antibiotic prophylaxis | Prolonged antibiotic prophylaxis is recommended only for preventing infection with S. pneumoniae among allogeneic recipients with cGVHD (see below). | |
Prevention of late bacterial infections with vaccinations | Immunizations (Table 6) are recommended for preventing infection with S. pneumoniae and H. influenzae type b | |
Prevention of bacterial infections among HCT recipients with severe hypogammaglobulinemia (ie, serum IgG level <400 mg/dL) | IVIG, 500 g/kg every 3-4 weeks (CIII) | None |
IVIG indicates intravenous immunoglobulin; HCT, hematopoietic cell transplantation; cGVHD, chronic graft-versus-host disease.
Notes: See the note in the previous table for IVIG administration for IgA-deficient patients.