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. 2009 Sep 9;15(10):1143–1238. doi: 10.1016/j.bbmt.2009.06.019

Pathogen: Methicillin-resistant Staphylococcus aureus (MRSA)

Indication First Choice Alternatives
Elimination of methicillin- resistant Staphylococcus aureus (MRSA) carrier state among HCT patients with recurrent MRSA infection (CIII)
  • Mupirocin calcium ointment 2% apply
    • •
      To nares 2 times/day for 5 days; or
    • •
      To wounds daily for 2 weeks

  • Daily bathing with a chlorhexidine product

  • Note: Safety of mupirocin in children <12 years old has not been established

 Systemic antimicrobials (eg, rifampin, doxycycline)

HCT indicates hematopoietic cell transplantation.

Note: No regimen for MRSA decolonization has proved consistently effective, but a decrease in MRSA burden may be accomplished.