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. 2009 Sep 9;15(10):1143–1238. doi: 10.1016/j.bbmt.2009.06.019

Patients at high risk for infections from molds or fluconazole-resistant Candida species

Indication First Choice Alternatives
Prophylaxis in the setting of prolonged neutropenia Micafungin, 50 mg i.v. once daily (BI)
Prophylaxis in the setting of GVHD Posaconazole, 200 mg orally 3 times daily (BI)

  • Voriconazole (BII)

  • Adults >40 kg: 4 mg/kg twice daily i.v. or 200 mg twice daily orally;

  • Pediatrics:

  • ≥ 20 kg: 100 mg twice daily i.v. or orally

  • < 20 kg: 50 mg twice daily i.v. or orally

GVHD indicates graft-versus-host disease.