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Schematic model for GR cross-talk with TNFα signaling on the IL-6 promoter in endocervical epithelial cells. A, TNFα stimulated IL-6 promoter in the presence of GR but the absence of glucocorticoids. B, TNFα stimulated IL-6 promoter in the absence of GR and glucocorticoids. C, TNFα stimulated IL-6 promoter in the presence of GR and glucocorticoids. “X” denotes an unidentified transcription factor, while “p” denotes a phosphorylated serine residue.
