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. 2011 Apr 13;286(22):19381–19391. doi: 10.1074/jbc.M111.218040

FIGURE 1.

FIGURE 1.

STK17A is induced with cisplatin in a variety of cell lines. A, STK17A is induced with cisplatin in cisplatin-sensitive human NT2/D1 cells but not in cisplatin-resistant NT2/D1-R1 cells. Real time PCR analysis was performed on RNA harvested 24 h following a 6-h cisplatin treatment. B and C, STK17A but not STK17B is induced with cisplatin in human U2OS osteosarcoma and A172 human glioblastoma cells treated with cisplatin as in A. Expression was measured by real time PCR. D and E, STK17B is induced with cisplatin in mouse NIH3T3 and mouse lung cancer ED1 cells. Real time PCR analysis was performed on RNA harvested 24 h following a 6-h cisplatin treatment. F, STK17A protein is induced with cisplatin in NT2/D1 and A172 cells as determined by Western analysis. The band representing STK17A is directly below the two nonspecific bands. All data points represent the average of biologic triplicates. Error bars are S.D. *, p < 0.01; **, p < 0.05. Data are representative of at least two independent experiments.