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. 2011 Apr 13;286(22):19381–19391. doi: 10.1074/jbc.M111.218040

FIGURE 4.

FIGURE 4.

STK17A contains a functional p53-responsive element. A, reporter assay of HCT116p53+/+ and HCT116p53−/− cells transfected with either TK-Luc control reporter or STK17A reporter (STK-TK-Luc; TK-Luc containing a 350-bp fragment surrounding STK17A-p53RE1) and either a control vector or DN-p53. B, reporter activity of NT2/D1 cells transfected with STK-TK-Luc or STK-TK-Luc-Mut (STK-TK-Luc where the core C and G in each half-site is mutated) and either control vector or DN-p53. C, the U251 cell line containing mutated p53 was transfected with TK-Luc control reporter or STK-TK-Luc or STK-TK-Luc-Mut reporter and either a control vector or a p53 expression vector. All data points are the average of biologic triplicate transfections. Error bars are S.D. *, p < 0.02. Data are representative of at least two independent experiments.