FIGURE 2.

Reactivation of VX-, cyclosarin-, sarin-, and paraoxon-inhibited hBChE by a library of 100 uncharged oxime reactivators at 0.67 mm determined by QuickScreen protocol (at 37 °C in 0.10 m phosphate buffer pH 7.4). Reactivation potency is given relative to 2PAM. Average reactivation potency of hBChE by oximes for all four organophosphates is given as yellow bars and for hAChE by red bars. Oxime IDs are ordered by their average reactivity (A) and segregated by their general structure as acetamide, imidazole and other oximes (B). Measured nonenzymic rates of ATCh hydrolysis by oximes (3 × ΔA/min) and calculated fractions of oximate anion for pH 7.4 are given as black and gray bars, respectively.