TABLE 1.

Structures and relative rate constants for OP-hAChE reactivation (k_obs) of 10 topmost uncharged reactivators (0.67 mm) compared with cationic pyridinium aldoxime 2PAM

Nonenzymic oximolysis rates of ATCh (1 mm) by 1.0 mm oximes and calculated percentages of oximate anion and neutral species at pH 7.4 (calculated by MarvinView 5.2.6) are also given. Experiments were performed in duplicate at 37 °C in 0.10 m phosphate buffer, pH 7.4.

* k_obs values determined for 2PAM were: 0.087 min⁻¹ (for POX), 0.16 min⁻¹ (for sarin), 0.025 min⁻¹ (for CS), 0.15 min⁻¹ (for VX) and 0.0026 min⁻¹ (as 1.0 mm for tabun).

** Not measured.