TABLE 2.

Structures and relative potencies for OP-hBChE reactivation of 10 topmost uncharged reactivators (0.67 mm) compared with cationic pyridinium aldoxime 2PAM determined by end- point QuickScreen procedure

Nonenzymic oximolysis rates of ATCh (1 mm) by 1.0 mm oximes and calculated percentages of oximate anion and neutral species at pH 7.4 (calculated by MarvinView 5.2.6) are also given. Experiments were performed in duplicate at 37 °C in 0.10 m phosphate buffer, pH 7.4.

* k_obs values determined in continuous reactivation assay for 2PAM were: 0.052 min⁻¹ (for POX), 0.13 min⁻¹ (for sarin), 0.17 min⁻¹ (for CS), 0.097 min⁻¹ (for VX), and 0.000461 min⁻¹ (as 1.0 mm for tabun).