TABLE 3.

Constants for reactivation of OP-hAChE conjugates by lead reactivator RS41A and reference reactivators MINA, DAM, and 2-PAM

The maximal reactivation rate constant (k₂), the Michaelis-type dissociation constant of OP-hAChE-oxime complex (K_ox), and overall second order reactivation rate constant (k_r) were calculated by nonlinear regression from plots presented in Fig. 3. Experiments were done in duplicate or triplicate at 37 °C in 0.10 m phosphate buffer, pH 7.4, and are summarized as shown in Fig. 3.