TABLE 4.

pH dependence of reactivation of VX-inhibited hAChE by lead oxime RS41A (1.0 mm), oximolysis of 1 mm ATCh by RS41A, and calculated concentration of oximate anion for RS41A (calculated by MarvinView 5.2.6)

Triplicate experiments (given is mean ± S.D.) were done in 0.1 m phosphate buffers.

pH	Reactivation		Oximolysis		[Oximate] @pH
	kobs	Ratio	Rate	Ratio		Ratio
	min−1		ΔA/min		%
6.4	0.19 ± 0.01	1	0.023 ± 0.003	1	0.02	1
7.4	0.16 ± 0.03	0.84	0.120 ± 0.007	6	0.20	10
8.4	0.17 ± 0.05	0.89	0.760 ± 0.096	34	1.5	75