FIGURE 5.
Intestinal HIF-2 expression is critical for the erythropoietic increase in serum iron. Wild-type (Hif-2αF/F) and intestinal HIF-2 knock-out (Hif-2αΔIE) mice were treated with PhZ or saline (Control), and sera were collected 2 (2d) and 7 (7d) days after the last injection. Serum was assayed for iron content. Four to five animals for each treatment group were assessed. Statistical analyses were performed using Student's t test. Error bars indicate S.D. *, p < 0.05; n.s., not significant.