TABLE 1.

SND1 global regulation of metastatic and oncogenic signaling programs

GSEA of control versus SND1-KD microarray analysis indicated 55 gene sets significantly down-regulated in the SND1-KD condition (p < 0.01 and false discovery rate (FDR) <0.25). Significantly down-regulated gene sets pertinent to metastasis and/or oncogenic signaling (n = 17) are shown. Gene sets tested for enrichment were obtained from the C2 collection provided in the Molecular Signatures Database v3.0 of the Broad Institute GSEA server. Nom, nominal; NES, normalized enrichment score; DMOG, dimethyloxalyl glycine.

Gene set	Size	NES	Nom p value	FDR q value
Minn lung metastasis up-regulated genes	43	2.25	<0.001	0.006
Amit EGF response 40 HeLa	38	2.14	<0.001	0.015
Amit serum response 40 MCF10A	28	2.13	<0.001	0.013
Bild HRas oncogenic signature	220	1.97	<0.001	0.076
Amit EGF response 120 MCF10A	39	1.83	<0.001	0.117
Nagashima EGF signature up	52	1.82	<0.001	0.116
Elvidge hypoxia by DMOG up	114	1.77	<0.001	0.156
Tomlins prostate cancer up	34	1.77	<0.001	0.151
Mense hypoxia up	80	1.77	<0.001	0.149
Elvidge hypoxia up	147	1.72	<0.001	0.162
Farmer breast cancer cluster 7	19	1.72	0.005	0.160
Wang Barrett esophagus cancer up	25	1.70	0.005	0.179
Winter hypoxia metagene	215	1.67	<0.001	0.191
Croonquist NRas vs. stromal stimulation up	33	1.64	0.006	0.211
Rickman head and neck cancer	78	1.64	0.003	0.213
Winter hypoxia up	81	1.61	<0.001	0.235
Wu cell migration	166	1.59	<0.001	0.244