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. Author manuscript; available in PMC: 2012 Jun 8.
Published in final edited form as: Neurosci Lett. 2011 Apr 12;496(3):152–156. doi: 10.1016/j.neulet.2011.04.004

Fig. 2. Calcium signaling was essential for MeHg-induced IL-6 release.

Fig. 2

Cells were pre-treated with PKC inhibitors (chelerythrine, Fig. 2A; H-7, Fig. 2B) or a calcium signaling inhibitor (2-APB, Fig. 2C) overnight followed by 5 μM MeHg (without the testing agent) overnight, and then IL-6 production and cell viability were determined. Results indicated that PKC inhibition had little effect on IL-6 release. In contrast, prevention of calcium signaling could significantly reduce IL-6 release. See text for more discussion on this issue.