Table 1.
A list of SNPs with significantly higher global FST (P < 0.05)
SNPs | Trait | Gene | RAF | Global FST | P value | Pcor |
---|---|---|---|---|---|---|
rs1378942 | Diastolic blood pressure [17] | CSK | 0.708 (G) | 0.247 | 0.025 | 0.022 |
rs653178 | Diastolic blood pressure [17] | ATXN2 | 0.177 (G) | 0.205 | 0.049 | 0.031 |
rs174570 | Total, HDL and LDL cholesterol [36] | FADS2 | 0.730 (C) | 0.351 | 0.002 | 0.000 |
rs4796217 | Macrophage-mediated inflammation [37] | CCL4L2 | 0.425 (T) | 0.221 | 0.040 | 0.032 |
rs602662* | Folate pathway [22,38] | FUT2 | 0.294 (A) | 0.240 | 0.027 | 0.028 |
rs9388489 | Type 1 diabetes [39] | C6orf97 | 0.634 (G) | 0.308 | 0.008 | 0.002 |
rs3184504* | Type 1 diabetes [39]; diastolic blood pressure and systolic blood pressure[17] | SH2B3 | 0.179 (T) | 0.210 | 0.045 | 0.031 |
rs6499640 | BMI and weight[40] | FTO | 0.455 (A) | 0.208 | 0.045 | 0.037 |
RAF: risk allele frequency; Pcor, P value after correcting for minor allele frequency; CSK, c-src tyrosine kinase; ATXN2, ataxin 2; FADS2, fatty acid desaturase 2; CCL4L2, chemokine (C-C motif) ligand 4-like 2; FUT2, fucosyltransferase 2; C6orf97, chromosome 6 open reading frame 173; SH2B3, SH2B adaptor protein 3; FTO, fat mass and obesity associated
*, non-synonymous SNPs