Table 2. Odds ratios (OR) and 95% confidence intervals (CI)A between variants in DCN and LUM genes and serous epithelial ovarian cancer risk.
| Discovery Set | Replication Set 1 | Combined Set | ||||||||
| MAY-NCO | AUS | MAY-NCO and AUS | ||||||||
| Gene/SNP rsID | Genotype | Case/control | OR (95%CI) | P | Case/control | OR (95%CI) | P | Case/control | OR (95%CI) | P |
| DCN | ||||||||||
| rs3138165B | ||||||||||
| GG | 353/778 | 1.0 (Ref) | 395/939 | 1.0 (Ref) | 748/1717 | 1.0 (Ref) | ||||
| GA | 43/138 | 0.7 (0.5–1.0) | 40/152 | 0.6 (0.4–0.9) | 83/290 | 0.7 (0.5–0.9) | ||||
| AA | 1/4 | 0.7 (0.1–6.2) | 0.17D | 1/7 | 0.4 (0.0–3.3) | 0.03D | 2/11 | 0.5 (0.1–2.1) | 0.006D | |
| Per allele | 0.7 (0.5–1.0) | 0.06E | 0.6 (0.4–0.9) | 0.009E | 0.7 (0.5–0.9) | 0.002E | ||||
| rs13312816C | ||||||||||
| AA | 353/778 | 1.0 (Ref) | 389/928 | 1.0 (Ref) | 742/1706 | 1.0 (Ref) | ||||
| AT | 43/138 | 0.7 (0.5–1.0) | 46/163 | 0.7 (0.5–0.9) | 89/301 | 0.7 (0.5–0.9) | ||||
| TT | 1/4 | 0.7 (0.1–6.2) | 0.17D | 1/7 | 0.4 (0.0–3.3) | 0.06D | 2/11 | 0.5 (0.1–2.1) | 0.01D | |
| Per allele | 0.7 (0.5–1.0) | 0.06E | 0.7 (0.5–0.9) | 0.01E | 0.7 (0.5–0.9) | 0.002E | ||||
| rs516115 | ||||||||||
| AA | 224/462 | 1.0 (Ref) | 229/543 | 1.0 (Ref) | 453/1005 | 1.0 (Ref) | ||||
| AG | 148/390 | 0.8 (0.6–1.0) | 164/442 | 0.9 (0.7–1.1) | 312/832 | 0.8 (0.7–1.0) | ||||
| GG | 23/67 | 0.7 (0.4–1.2) | 0.14D | 37/109 | 0.8 (0.5–1.2) | 0.43D | 60/176 | 0.8 (0.6–1.1) | 0.07D | |
| Per allele | 0.8 (0.7–1.0) | 0.06E | 0.9 (0.8–1.1) | 0.20E | 0.9 (0.8–1.0) | 0.03E | ||||
| rs741212 | ||||||||||
| AA | 313/699 | 1.0 (Ref) | 325/830 | 1.0 (Ref) | 638/1529 | 1.0 (Ref) | ||||
| AG | 81/210 | 0.9 (0.6–1.2) | 103/247 | 1.1 (0.8–1.4) | 184/457 | 1.0 (0.8–1.2) | ||||
| GG | 3/11 | 0.7 (0.2–2.4) | 0.53D | 8/19 | 1.1 (0.5–2.7) | 0.88D | 11/30 | 1.0 (0.5–1.9) | 0.93D | |
| Per allele | 0.9 (0.7–1.1) | 0.26E | 1.1 (0.8–1.3) | 0.61E | 1.0 (0.8–1.2) | 0.71E | ||||
| LUM | ||||||||||
| rs17018765B | ||||||||||
| AA | 354/776 | 1.0 (Ref) | 395/939 | 1.0 (Ref) | 749/1715 | 1.0 (Ref) | ||||
| GA | 42/141 | 0.7 (0.5–1.0) | 40/152 | 0.6 (0.4–0.9) | 82/293 | 0.7 (0.5–0.8) | ||||
| GG | 1/3 | 0.9 (0.1–8.6) | 0.12D | 1/7 | 0.4 (0.0–3.3) | 0.03D | 2/10 | 0.5 (0.1–2.4) | 0.005D | |
| Per allele | 0.7 (0.5–1.0) | 0.06E | 0.6 (0.4–0.9) | 0.008E | 0.6 (0.5–0.8) | 0.001E | ||||
A
Adjusted for region of residence (Minnesota, Iowa, Wisconsin, Illinois, North Dakota, South Dakota and North Carolina) for MAY and NCO studies; and adjusted for site (MAY, NCO and AUS) for the combined analysis. Sample is 1,317 Caucasian subjects in the discovery set and 1,534 Caucasian subjects in replication set 1.
B
Imputed in replication set 1 (AUS).
C
Imputed in discovery set (MAY and NCO).
D
P-value for two degrees of freedom test.
E
P-value for the ordinal model.