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. 2011 May 27;6(5):e18889. doi: 10.1371/journal.pone.0018889

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Nguyen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A procedure randomly picks a gene-set with N genes from the background and search for common CRMs (δ = 0.7) in that gene-set. The statistical significant p-value for each CRM is estimated and the minimum one is reported. Each point in the blue curve is a transformed value of the mean of the minimum p-values of CRMs in 100 times running the procedure for the corresponding k. Approximately, the red curve shows which thresholds should be used for the non-random cases. After N = 14 genes, only one threshold is used to ensure the significance (p-value = 0.01).