Table 4. Critical transcription factors identified from the in vitro endotoxin study.

No.	Patterns	Functions	Transcription factors*
1	Early-up	Apoptosis	CLOX, E2FF, EGRF, EKLF, ETSF, FKHD, HOXC, HOXF, IRFF, MAZF, NKXH, NOLF, OCT1, RXRF, SORY, SP1F, STAT, XBBF
2	Late-up	Apoptosis	CREB, EKLF, MAZF, NFKB, SORY, ZBPF
3	Early-up	Toll-like receptor signaling pathway	AP1R, CLOX, E2FF, EGRF, EKLF, ETSF, HOXC, IRFF, NFKB, NOLF, NR2F, OCT1, RXRF, SORY, SP1F, STAT, XBBF, ZBPF
4	Late-up	Toll-like receptor signaling pathway	ABDB, CLOX, ETSF, HOMF, HOXF, IRFF, NFKB, NKXH, RXRF, SORY, STAT, TBPF
5	Early-up	Cytokine-cytokine receptor interaction	CREB, ETSF, FKHD, HOXF, RXRF, STAT, TBPF
6	Late-up	Cytokine-cytokine receptor interaction	ABDB, HOXF, NR2F, OCT1, RXRF, SORY, STAT
7	Early-up	Jak-STAT signaling pathway	ABDB, AP1R, AP4R, E2FF, EGRF, EKLF, ETSF, FKHD, HOMF, HOXF, IRFF, MAZF, NKXH, RXRF, SORY, SP1F, STAT, TBPF, XBBF, ZBPF
8	Late-up	Jak-STAT signaling pathway	ABDB, AP1R, AP4R, CLOX, CREB, E2FF, ETSF, FKHD, HOMF, HOXC, HOXF, NKXH, NR2F, OCT1, RXRF, SORY, TBPF
9	Up-remained	Pyrimidine metabolism	AP4R, E2FF, EGRF, EKLF, ETSF, FKHD, HOXF, MAZF, NFKB, NKXH, NOLF, NR2F, RXRF, SP1F, XBBF, ZBPF