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. 2011 May 27;6(5):e19544. doi: 10.1371/journal.pone.0019544

Figure 7. Single therapy using anti-TNFα (Iα).

Figure 7

The system is first allowed to reach low steady states of all variables, and then exposed to a square pulse of antigen with amplitude A = 100 from t = 20 to t = 70 (indicated by the first two black arrows from the left) to obtain a sarcoid state. (A) Without anti-TNFα (Iα = 0). (B) Anti-TNFα is introduced as a square pulse with amplitude Iα = 21.1 from t = 100 to t = 140 (indicated by the last pair of thick gray arrows); (C) Anti-TNFα is introduced as a square pulse with amplitude Ia = 21.2 from t = 100 to t = 140 (indicated by the last pair of thick gray arrows). All parameters as in Table 2, except k2a = 2.1 and k2b = 0.2.