Skip to main content
. Author manuscript; available in PMC: 2012 Feb 18.
Published in final edited form as: Pflugers Arch. 2011 Feb 18;461(4):447–459. doi: 10.1007/s00424-011-0926-5

Figure 3. Rim1 does not affect the maximal G-protein inhibition of Cav2.2 channel.

Figure 3

A, Representative normalized Ba2+ current traces elicited at +10 mV and +30 mV before (IControl) and after 10 μM DAMGO application (IDAMGO) for Cav2.2/β3/α2δ1b channels (top panel). Corresponding traces allowing the measurement of the maximal DAMGO inhibition at the start of the depolarization (GIt0) (bottom panel). IControl and ILost (obtained by subtracting IDAMGO from IControl) were fitted (red dashed lines) by a mono- and a double-exponential function, respectively, in order to better estimate GIt0. B, Legend as in (a) but for cells expressing Cav2.2/β3/α2δ1b/Rim1 channels. C, Corresponding mean values of GIt0 for Cav2.2/β3/α2δ1b (filled bars) and Cav2.2/β3/α2δ1b/Rim1 channels (open bars) as a function of membrane potential. Values were not altered by the presence of Rim1.