Figure 4.
Lung tissue from aerosolized LPS-treated rats show more diffuse distribution of inflammatory cells than lungs from rats intratracheally instilled with LPS. Photomicrographs of H&E-stained tissue sections prepared from lung tissues at airway generation 5 in the left lung of rats exposed to (A) filtered air, (B) intratracheally instilled with LPS, or (C) to aerosolized LPS. Darkly stained tissue is indicative of inflammation. Note the even distribution of light staining tissue in the lungs exposed to aerosolized LPS compared to the localized dark stained tissue in the lungs of rats intratracheally instilled with LPS.