Table 2.

Bone Histomorphometric Parameters

Bone Histomorphometric parameters	Reference Children 11–13.9 yrs*	P1	P1 vs. controls	P1 vs. OI	P2	P2 vs. controls	P2 vs. OI	OI Type I**
BV/TV	24.4 ± 4.2	27.83	0.82	3.24	19.87	−1.08	1.70	11.0 ± 5.2
mdBV/TV	23.9 ± 4.5	23.48	−0.09		18.32	−1.24
Tb.Th. [μm]	148 ± 23	115.74	−1.40	0.43	107.65	−1.75	0.11	105 ± 25
Tb.N. [1/mm]	1.66 ± 0.22	2.40	3.36	3.50	1.85	0.86	2.10	1.03 ± 0.39
OV/BV [%]	2.12 ± 1.00	15.63	13.51	4.01	7.79	5.67	1.00	5.2 ± 2.6
O.Th. [μm]	6.7 ± 1.7	19.01	7.24	7.95	6.94	0.14	0.85	5.5 ± 1.7
OS/BS [%]	22.1 ± 7.8	60.93	4.98	0.91	80.34	−1.76	2.31	48 ± 14
Ob.S/BS [%]	6.7 ± 4.5	9.21	0.56	−1.07	6.02	−0.71	−1.41	19.4 ± 9.5
Oc.S/BS [%]	0.94 ± 0.38	2.05	2.92	/	0	−2.47	/	1.37 [1.05–1.70]
ES/BS [%]	14.9 ± 5.6	29.70	2.64	/	11.27	−0.65	/	15.6 [13.7 - 21.8]
N.Oc/BS [1/mm]	0.29 ± 0.14	0.45	1.14	−0.06	0	−2.01	−1.62	0.47 ± 0.29
MS/BS [%]	11.7 ± 5.0	16.50	0.96	−0.68	5.40	−1.26	−1.83	23.1 ± 9.7
MAR [μm/d]	0.87± 0.09	1.20	3.67	2.60	1.40	5.89	3.72	0.73 ± 0.18
BFR/BS [μm3/μm2/y]	37.3 ± 16.7	72.30	2.09	−0.14	27.60	−0.58	−1.45	77 ± 34

^*(Glorieux et al., 2000)

^**(Rauch et al., 2000)

#Z-score:

We considered an increase if the value was more than 1 SD above controls/OI i.e. > 1

We considered a decrease if value is more than 1 SD below controls/OI i.e. < -1

We considered normal if value is between -1 and 1