Table 3.
BMDD Parameters
| BMDD- parameters | Young Reference n=54a | Single Control | Diff. [%] | Patient 1 | Diff [%] | Patient 2 | Diff [%] | α2(I) G190V | Diff [%] | α2(I) G940D | Diff [%] | OI type I n = 19b | Diff [%] |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CaMean [wt% Ca] | 20.95 (0.57) | 21.10 | 0.72 | 21.56 | 2.90*** | 24.07 | 14.91*** | 22.81 | 8.88 | 22.87 | 9.16 | 22.43 (0.63) | 7.06 |
| CaPeak [wt% Ca] | 21.66 (0.52) | 21.84 | 0.83 | 23.05 | 6.41*** | 25.30 | 16.81*** | 23.91 | 10.39 | 23.74 | 9.60 | 23.39 (0.57) | 7.99 |
| CaWidth [Δwt% Ca] | 3.47 [3.12;3.64] | 3.29 | −5.19 | 4.85 | 39.77*** | 3.12 | −10.09*** | 3.64 | 4.90 | 3.12 | −10.09 | 3.08 (0.28) | −11.24 |
| CaLow [%] | 6.14 [4.95;7.99] | 6.27 | 2.12 | 11.80 | 92.11*** | 5.72 | −6.84*** | 6.47 | 5.37 | 4.85 | −21.01 | 5.94 (2.05) | −3.26 |
| CaHigh [%] | 0.90 [0.44;1.47] | 1.27 | 42.70 | 12.72 | 1329.50 *** | 45.33 | 4993.10*** | 18.08 | 1931.46 | 10.20 | 1046.07 | 7.54 [5.00;11.82] | 737.00 |
Data are mean (SD) or median [25th percentile; 75th percentile]
Diff. = difference to Young Reference
***
p<0.001 versus Young Referencea (one-sample t-test and Wilcoxon signed-rank test, correspondingly)