Table 5.

NMR Data for Veraguamide G (7) and Tetrahydroveraguamide A (8) in CDCl₃

			7		8
unit	C/H no.	δ Ca	δH (J in Hz)b	δCb,c	δH (J in Hz)b
Hmoead/Hmoaae	1	170.9, C		170.7, C
	2	42.4, CH	3.10, br q (7.4)	42.1, CH	3.08, br q (7.4)
	3	76.8, CH	4.85, dt (10.6, 2.4)	76.8, CH	4.86, dt (10.1, 2.1)
	4a	27.9, CH2	1.98, m	31.0, CH2	1.21, m
	4b		1.45, m		1.26, m
	5a	25.5, CH2	1.48, m	28.2, CH2	1.39, m
	5b		1.30, m
	6a	33.2, CH2	2.05, m	25.8, CH2	1.39, m
	6b				1.20, m
	7	138.2, CH	5.74, m	22.2, CH2	1.26, m
	8	114.9, CH2	4.97, m	13.6, CH3	0.85, t (6.9)
	9	14.4, CH3	1.22, d (7.4)	14.0, CH3	1.23, d (7.4)
N-Me-Val-1	1	170.7, C		170.7, C
	2	65.0, CH	3.93, d (9.8)	64.9, CH	3.93, d (10.7)
	3	28.3, CH	2.28, m	28.3, CH	2.28, m
	4	19.59, CH3	0.98, d (6.4)	19.2, CH3	0.98, d (6.5)
	5	19.54, CH3	0.92, d (6.4)	19.3, CH3	0.91, d (6.5)
	N-Me	28.6, CH3	3.01, s	28.4, CH3	3.00, s
Pro	1	172.2, C		172.0, C
	2	57.3, CH	4.95, dd (8.7, 5.0)	57.1, CH	4.94, dd (9.0, 5.0)
	3a	29.4, CH2	2.29, m	29.1, CH2	2.28, m
	3b		1.79, m		1.79, m
	4a	24.9, CH2	2.03, m	24.6, CH2	2.03, m
	4b		1.98, m		1.99, m
	5a	47.3, CH2	3.84, dt (−16.7, 7.1)	47.0, CH2	3.84, dd (−17.0, 7.3)
	5b		3.61, dt (−16.7, 7.1)		3.60, dd (−17.0, 7.3)
Hmpa	1	165.9, C		165.7, C
	2	76.0, CH	4.90, d (8.7)	76.6, CH	4.90, d (8.8)
	3	35.7, CH	1.98, m	35.4, CH	1.98, m
	4	24.8, CH2	1.54, m	24.5, CH2	1.54, m
			1.13, m		1.13, m
	5	10.5, CH3	0.86, t (7.3)	10.2, CH3	0.86, t (7.1)
	6	13.8, CH3	1.00, d (6.0)	13.5, CH3	1.00, d (6.4)
N-Me-Val-2	1	169.6, C		169.5, C
	2	66.0, CH	4.15, d (10.2)	65.8 CH	4.14, d (9.6)
	3	28.6, CH	2.28, m	28.1, CH	2.28, m
	4	20.4, CH3	1.00, d (6.1)	20.0, CH3	0.99, d (6.6)
	5	20.2, CH3	1.10, d (6.1)	19.9, CH3	1.10, d (6.6)
	N-Me	30.0, CH3	2.93, s	29.7, CH3	2.93, s
Val	1	173.4, C		173.3, C
	2	52.7, CH	4.70, dd (8.6, 6.7)	52.5, CH	4.70, dd (8.6, 6.2)
	3	32.1, CH	1.98, m	31.7, CH	1.96, m
	4	20.3, CH3	0.93, d (6.8)	19.3, CH3	0.93, d (6.3)
	5	17.6, CH3	0.86, d (6.8)	17.2, CH3	0.87, d (6.3)
	NH		6.23, d (8.6)		6.26, d (8.6)

^a125 MHz

^b600 MHz

^cBased on HSQC and HMBC

^dRefers to Compound 7

^eRefers to Compound 8