Table 2.

Baseline disease activities in TNF-low, TNF-int and TNF-high patients

	Baseline-TNF
	TNF-low (n=94)	TNF-int (n=191)	TNF-high (n=42)	p Value (overall)
DAS28-CRP	5.3 (4.9, 5.9)	5.5 (5.0, 6.2)	5.9 (5.2, 6.7)	0.002
DAS28-ESR	5.9 (5.5, 6.4)	6.2 (5.7, 6.8)	6.8 (6.2, 7.3)	<0.001
TJC, 68 joints	14.0 (10.0, 21.0)	15.0 (11.0, 23.0)	16.5 (12.0, 23.0)	0.153
SJC, 66 joints	11.0 (8.0, 16.0)	13.0 (9.0, 17.0)	12.5 (10.0, 18.0)	0.041
Patient pain VAS, mm	49.0 (37.0, 65.0)	58.0 (40.0, 72.0)	68.5 (46.0, 88.0)	<0.001
Patient global VAS, mm	51.0 (36.0, 64.0)	56.0 (36.0, 72.0)	65.0 (43.0, 86.0)	0.016
Physician global VAS, mm	62.0 (50.0, 75.0)	65.0 (49.0, 77.0)	72.0 (51.0, 82.0)	0.081
CRP (mg/dl)	2.0 (1.0, 3.9)	2.4 (1.2, 3.9)	2.8 (1.4, 5.8)	0.028
ESR (mm/h)	46.0 (33.0, 65.0)	53.0 (35.0, 72.0)	67.5 (40.0, 89.0)	0.001
HAQ	1.0 (0.5, 1.4)	1.1 (0.9, 1.6)	1.4 (1.0, 2.1)	0.002
TSS	37.0 (10.5, 76.0)*	36.0 (12.5, 72.3)†	22.5 (13.0, 56.0)	0.960
Estimated yearly progression of TSS, point/year	5.8 (2.8, 12.0)*	6.3 (3.4, 11.3)†	5.5 (2.5, 10.0)	0.833
RF value, IU/ml	85 (27, 215)	81 (37, 167)	238 (126, 554)	0.007
Anti-CCP antibodies value, IU/ml	91 (17, ≥100)	≥100 (30, ≥100)	≥100 (≥100, ≥100)	0.012
MMP-3 value, ng/ml	205 (105, 377)	216 (102, 391)	268 (114, 640)	0.214

Data in baseline value are median (IQR).

Baseline disease activities were evaluated in the patients enrolled in the RISING study (n=327). The associations of baseline-tumour necrosis factor alpha (TNF) with baseline disease activities were analysed in the three groups (TNF-low, TNF-int and TNF-high patients) employing the Kendall rank correlation coefficient.

^*n=93.

^†n=190.

CCP, cyclic citrullinated peptide; CRP, C-reactive protein; DAS28, disease activity score in 28 joints; ESR, erythrocyte sedimentation rate; HAQ, health assessment questionnaire; MMP-3, matrix metalloproteinase 3; RF, rheumatoid factor; SJC, swollen joint count; TJC, tender joint count; TSS, total modified Sharp score; VAS, visual analogue scale.