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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Nat Neurosci. 2011 May 15;14(6):711–717. doi: 10.1038/nn.2803

Figure 1. Cell-attached spikes result from spontaneous APs.

Figure 1

(a and b), Spontaneous APs recorded with whole-cell current clamp and cell-attached voltage clamp, respectively. Right panels show an action potential on an expanded time-scale. (c and d), Whole-cell (top panels) and cell-attached (bottom panels) recordings of spontaneous APs in mouse apical-coil IHCs during the application of a Ca2+-free solution containing 0.5 mM EGTA (c), a condition that abolishes this activity14. During the perfusion of a solution containing 15 mM K+ (d) IHCs depolarized causing the frequency of spikes to increase while their amplitude declined. In this and the following figures, the duration of substance application is indicated by the horizontal line above the recording.