Figure 7.

SS-31 reduces renal medullary vascular congestion 1 hour after IR injury. Rats were subcutaneously treated with saline or SS-31 (2 mg/kg) 30 minutes before occlusion of renal blood flow for 45 minutes. Treatment was repeated just before onset of reperfusion, and kidney sections were stained with hemotoxylin and eosin. Representative sections from the ISOM are shown in panels A through C, and representative sections from the inner medulla are shown in panels D through F (magnification: ×200). Inset shows higher magnification of the area identified by the arrow. Kidneys from Sham-operated rats showed minimal erythrocyte trapping in ISOM and the inner medulla (A, D). Extensive trapping of erythrocytes was found in ISOM and the inner medulla in the saline-treated IR group (B, E). Erythrocyte trapping was greatly reduced in the SS-31-treated IR group (C, F).