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. 2011 Jun;22(6):1041–1052. doi: 10.1681/ASN.2010080808

Figure 8.

Figure 8.

SS-31 reduces renal oxidative stress caused by IR. Rats were subcutaneously treated with saline or SS-31 (2 mg/kg) 30 minutes before occlusion of renal blood flow for 45 minutes. (A) Effects of SS-31 on renal GSH level after 1-hour reperfusion. n = 6 to 8 in each group. ANOVA, P < 0.05. *P < 0.05 compared with Sham. GSH level in the SS-31-treated IR animals was not different from Sham. (B) Effects of SS-31 on lipid hydroperoxides after 24-hour reperfusion as measured by MDA in renal medullary tissues. n = 3 to 4 in each group. ANOVA, P = 0.01. *P < 0.05 compared with Sham-operated animals. (C) Effects of SS-31 on HO-1 expression at 24 hours after IR injury. Representative western blot for HO-1 from Sham, saline IR, and SS-31 IR animals is shown with β-actin as a loading control. n = 11 to 12 in each group. ANOVA, P < 0.0001. HO-1 protein expression was significantly increased in saline and SS-31 IR animals (***P < 0.001 compared with Sham); however, HO-1 expression in SS-31 animals was significantly lower than saline (*P < 0.05).