Figure 7.

Af17^−/− and Af17^+/+ mice show similar renal physiology and BP in a time-dependent manner on the low Na⁺ diet. Af17^+/+ (solid line or dark bar) and Af17^−/− (dotted line or gray bar) mice were fed the low Na⁺ diet (0.02% Na⁺) in metabolic cages and analyzed for the parameters before (day 0) and after treatment at various time points as indicated. For BP measurement, n = 17 to 21 mice/group. For all other parameters, n = 4 to 14 for Af17^+/+ mice and n = 6 to 14 for Af17^−/− mice. For additional parameters, see Supplemental Figure S4. In all cases, *P < 0.05 versus Af17^+/+.