Table 2.

Results of the piecewise proportional hazards model for the relationship between dialysis modality and death

	Adjustedb Time dependenta HR [95% CI]		Univariate Time dependenta HR [95% CI]	Adjustedb Time dependenta HR [95% CI]	Adjustedb Time averagec HR [95% CI]
Overalld
PD	1.0	PD	1.0	1.0	1.0
HD	1.0 [1.0, 1.1]	HD-CVC	1.7 [1.6, 1.7]	1.2 [1.1, 1.2]	1.2 [1.1 1.2]
		HD-AVF/AVG	1.1 [1.0, 1.1]	0.8 [0.8, 0.9]	0.8 [0.8,0.9]
Year 1
PD	1.0	PD	1.0	1.0	1.0
HD	1.5 [1.4,1.7]	HD-CVC	2.7 [2.4, 2.9]	1.8 [1.6, 1.9]	1.6 [1.5, 1.8]
		HD-AVF/AVG	1.1 [1.0, 1.3]	0.9 [0.8, 1.1]	0.9 [0.8,1.1]
Year 2
PD	1.0	PD	1.0	1.0	1.0
HD	1.0 [0.9, 1.1]	HD-CVC	1.5 [1.4, 1.6]	1.1 [1.0, 1.2]	1.4 [1.3, 1.5]
		HD-AVF/AVG	0.9 [0.8, 1.0]	0.8 [0.7, 0.9]	0.8 [0.8,0.9]
Year 3
PD	1.0	PD	1.0	1.0	1.0
HD	0.8 [0.7, 0.9]	HD-CVC	1.2 [1.1, 1.4]	0.9 [0.8, 1.0]	1.2 [1.2, 1.3]
		HD-AVF/AVG	0.9 [0.8, 1.0]	0.7 [0.6, 0.8]	0.8 [0.7, 0.9]
Year 4
PD	1.0	PD	1.0	1.0	1.0
HD	0.8 [0.7,1.0]	HD-CVC	1.3 [1.1, 1.5]	0.9 [0.8, 1.0]	1.2 [1.1, 1.2]
		HD-AVF/AVG	1.1 [0.9, 1.3]	0.8 [0.7, 1.0]	0.8 [0.7,0.9]
Year 5
PD	1.0	PD	1.0	1.0	1.0
HD	0.8 [0.7, 0.9]	HD-CVC	1.2 [1.1, 1.5]	0.9 [0.7, 1.0]	1.2 [1.1,1.2]
		HD-AVF/AVG	1.1 [0.9, 1.3]	0.8 [0.7, 1.0]	0.8 [0.8,0.9]

^aTime-dependent hazard ratios within each year were used to assess annual mortality risk.

^bIntention to treat, adjusted for age, race, gender, era of dialysis initiation, end-stage renal disease comorbidity index, primary renal diagnosis, serum albumin, estimated glomerular filtration rate, province of treatment, and late referral.

^cTime-averaged hazard ratios from a proportional hazards model were used to assess the cumulative treatment effect from day 0 through the end of years 1 to 5, respectively.

^dOverall model and time average models constructed using 29,647 subjects using proportional hazards model, remainder of time-dependent models using nonproportional hazards model.