Table 3.
Results of the sensitivity analysis, piecewise proportional hazards model for the relationship between dialysis modality and death
| Censored at 60 Days after Modality Switcha | Modality at 90 Days after Dialysis Initiationa | Multiple Imputation of Missing Dataa,b | IPTCWa,c | Exclusion of Late-referral Patientsa,d | |
|---|---|---|---|---|---|
| Overall | |||||
| PD | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| HD-CVC | 1.2 (1.1, 1.2) | 1.1 (1.0, 1.1) | 1.2 (1.1, 1.2) | 1.1 (1.0, 1.1) | 1.1 (1.1, 1.2) |
| HD-AVF/AVG | 0.8 (0.8, 0.9) | 0.8 (0.7, 0.9) | 0.8 (0.8, 0.9) | 0.7 (0.6, 0.8) | 0.8 (0.8, 0.9) |
| Year 1 | |||||
| PD | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| HD-CVC | 1.8 (1.6, 2.0) | 1.4 (1.3, 1.6) | 1.8 (1.6, 1.9) | 1.3 (1.1, 1.5) | 1.6 (1.5, 1.8) |
| HD-AVF/AVG | 1.0 (0.9, 1.2) | 0.9 (0.8, 1.0) | 0.9 (0.8, 1.0) | 0.7 (0.6, 0.9) | 1.0 (0.9, 1.1) |
| Year 2 | |||||
| PD | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| HD-CVC | 1.1 (1.0, 1.3) | 1.1 (1.0, 1.2) | 1.0 (0.9, 1.1) | 1.1 (1.0, 1.3) | 1.0 (0.9, 1.2) |
| HD-AVF/AVG | 0.9 (0.8, 1.0) | 0.8 (0.7, 0.9) | 0.7 (0.7, 0.8) | 0.8 (0.6, 1.1) | 0.8 (0.7, 0.9) |
| Year 3 | |||||
| PD | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| HD-CVC | 0.9 (0.8, 1.0) | 0.9 (0.8, 1.0) | 0.9 (0.8, 1.0) | 0.9 (0.7, 1.0) | 0.9 (0.8, 1.0) |
| HD-AVF/AVG | 0.7 (0.6, 0.8) | 0.7 (0.6, 0.8) | 0.7 (0.6, 0.8) | 0.5 (0.4, 0.7) | 0.7 (0.6, 0.8) |
| Year 4 | |||||
| PD | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| HD-CVC | 0.9 (0.7, 1.0) | 0.9 (0.8, 1.0) | 0.9 (0.8, 1.0) | 0.9 (0.7, 1.1) | 0.9 (0.8, 1.1) |
| HD-AVF/AVG | 0.8 (0.6, 1.0) | 0.8 (0.7, 0.9) | 0.9 (0.7, 1.0) | 0.8 (0.5, 1.2) | 0.8 (0.7, 0.9) |
| Year 5 | |||||
| PD | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| HD-CVC | 0.7 (0.6, 0.9) | 0.8 (0.7, 1.0) | 0.9 (0.7, 1.0) | 1.0 (0.8, 1.3) | 0.9 (0.8, 1.1) |
| HD-AVF/AVG | 0.7 (0.6, 1.0) | 0.8 (0.6, 1.0) | 0.9 (0.7, 1.0) | 0.9 (0.6, 1.4) | 0.8 (0.6, 0.9) |
IPTCW, inverse probability of treatment and censoring weighting.
aAdjusted for age, race, gender, era of dialysis initiation, end-stage renal disease comorbidity index, primary renal diagnosis, serum albumin, estimated glomerular filtration rate, province of treatment, and late referral.
bAssuming monotone missing pattern, the predictive mean matching method was used to impute missing values.
cPairwise PD-HD(CVC) and PD-HD(AVF/AVG) propensity scores were used.
dExclusion of 11,076 HD-CVC, 1126 PD, and 240 HD-AVF/AVG patients who had 3 months or less of predialysis care by a nephrologist.