Table 3.

Change in eGFR over 54 weeks by treatment group

Treatment	eGFR Change (ml/min per 1.73 m2)	eGFR Change with Imputation (ml/min per 1.73 m2)
Placebo	−2.2 ± 4.8	−3.7 ± 5.7
Pirfenidone at 1200 mg/d	3.3 ± 8.5a	3.3 ± 8.5b
Pirfenidone at 2400 mg/d	−1.9 ± 6.7	−2.1 ± 6.4
Total	−0.3 ± 7.0	−0.7 ± 9.1

Shown are the eGFR changes over the course of the study in the 52 study completers and in the 52 completers plus the 5 subjects who began dialysis during the study, for whom an end-of-study eGFR was imputed as 10 ml/min per 1.73 m².

^aP = 0.026 versus placebo and

^bP < 0.006 versus placebo.