Table 5.

Association of baseline plasma biomarker levels with baseline eGFR in completers

Biomarker	n	Change GFR (95% CI)	P
IFN-γa	48	−5.1 (−8.7, −1.5)	0.006
IL-1a	48	−4.4 (−8.1, −0.8)	0.019
TNF	48	−6.7 (−10.0, −3.3)	<0.001
sTNF-R1	47	−9.0 (−11.9, −6.2)	<0.001
FGF-23a	48	−8.1 (−11.2, −5.0)	<0.001
YKL-40	47	−4.8 (−8.5, −1.1)	0.011
Brain natriuretic peptidea	46	−0.9 (−4.8, 3.1)	0.667

Shown are the cross-sectional associations of biomarkers at the baseline study visit with eGFR at the baseline study visit using linear regression. Negative values indicate that higher baseline biomarker level was associated with a lower GFR at the baseline study visit.

^aSkewed variables were natural log transformed, and each biomarker was subsequently modeled as per 1 SD higher to facilitate comparison in strengths of association.