Table 2.

Impact of kidney transplantation on the hazard rate of death (n = 175, 64 deaths: 28 pretransplant and 36 post-transplant)

Predictor Variables in the Modela	Cox Model (Coefficient ± SE)	Wald Test (P)	Adjusted Relative Risk [95% Confidence Interval]
Post-Tx effect during 0 to 6 monthsb	0.922 ± 0.414	0.03	2.51 [1.12 to 5.66]
Post-Tx effect >6 and ≤84 monthsbc	−1.140 ± 0.336	0.0007	0.32 [0.17 to 0.62]
Post-Tx effect >84 monthsc	−0.307 ± 0.704	0.66	0.74 [0.19 to 2.92]
Listed for kidney/pancreas Txd	1.160 ± 0.355	00.001	3.19 [1.59 to 6.39]
Age at listing ≥55 years	0.864 ± 0.296	0.004	2.37 [1.33 to 4.24]
White race	0.589 ± 0.262	0.02	1.80 [1.08 to 3.01]

Tx, transplant.

^aThree distinct post-transplant effect time periods, adjusting for three significant baseline covariates. Of note, the effect of kidney transplantation during six distinct post-transplant time periods was initially considered, i.e., 0 to 3, 4 to 6, 7 to 12, 13 to 48, 49 to 84, and >84 months. Likelihood ratio tests of the impact of transplantation were not significantly different (1) during the first two periods (i.e., 0 to 6 months, P = 0.20) and (2) during the next three periods (i.e., 7 to 84 months, P = 0.73). Among the 36 post-transplant deaths, there were 9, 17, and 10 deaths that occurred during 0 to 6, 6 to 84, and >84 months after transplantation, respectively.

^bLikelihood ratio test (with 1 df) for equality of the post-transplant effects during 0 to 6 and 6 to 84 months after transplant yielded P < 0.001.

^cLikelihood ratio test (with 1 df) for equality of the post-transplant effects during 6 to 84 and >84 months after transplant yielded P = 0.22.

^dAll patients listed for a kidney-pancreas transplant were type 1 diabetics.