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. Author manuscript; available in PMC: 2012 Mar 20.
Published in final edited form as: Dev Dyn. 2010 Dec 7;240(3):477–485. doi: 10.1002/dvdy.22504

Figure 1. Signaling interactions during step-wise specification of the respiratory lineage.

Figure 1

Schematic depictions of key secreted ligands and transcription factors involved in specifying the respiratory progenitors. (A) During gastrulation, signals secreted from the adjacent mesoderm and ectoderm specify the foregut endoderm, which expresses marker genes Hhex and Sox2. (B) As the gut tube folds, multiple signals interact to induce trachea and lung fate in the ventral endoderm. NOG = Noggin, CHO = Chordin