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. Author manuscript; available in PMC: 2012 Apr 22.
Published in final edited form as: Chem Biol. 2011 Apr 22;18(4):531–541. doi: 10.1016/j.chembiol.2010.12.021

Figure 5. Ischemin functions a cellular protective agent against myocardial ischemic stress.

Figure 5

(A) TUNEL assay showing ischemin inhibition of doxorubicin-induced apoptosis in rat neonatal cardiomyocytes. (B) Evaluation of ischemin effects in U2OS cells and cardiomyocytes. The immunoblots show down-regulation of doxorubicin-induced activated p53 in both cell types in the presence of ischemin, while levels of H2XS139p remained the same. (C) Inhibition of doxorubicin-induced caspase 3/7 activation in cardiomyocytes by ischemin. See also Figure S4.