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Pedigrees of the 6 kindreds with MyD88 deficiency identified. Each kindred with MyD88 deficiency is designated by a lower case letter (a-f) ; each generation is designated by a Roman numeral (I–IV), and each individual is designated by an Arabic numeral (from left to right). Patients with a clinical phenotype are indicated by closed symbols. In each family, the proband is indicated by an arrow. Individuals whose genetic status could not be evaluated are indicated by “E?”.
