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Deletion of β1 integrin using Tamoxifen. (a) No Tamoxifen, gene active. The active gene, β1 integrin, resides floxed in the nucleus. Complexes of Hsp90 (red) and CreERδ (green) reside in the cytoplasm. (b) Tamoxifen added, gene inactive. When Tamoxifen is added, CreERδ (green) is dissociated from Hsp90 (red), allowing it to translocate to the nucleus and remove the floxed β1 integrin.
