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. Author manuscript; available in PMC: 2012 Mar 16.
Published in final edited form as: J Am Chem Soc. 2011 Feb 22;133(10):3339–3341. doi: 10.1021/ja109824x

Table 3.

Asymmetric Michael Reaction of Oxindoles and Methyl Vinyl Ketone Catalyzed by Ca[P1]2a

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a

Reaction conditions: 1 (1.0 equiv), methyl vinyl ketone (3.0 equiv), and 2.5 mol % catalyst at 0 °C. Yields reported are isolated. Enantiomeric excess was determined by Chiral HPLC Analysis. The (R)-VAPOL derived salt was used in each example.